Pr. Valérie de Crécy-Lagard, Distinguished Professor, Department of Microbiology and Cell Science & Genetics Institute, University of Florida will give a seminar entitled " From Genes to Mechanisms: Unveiling Functional Mysteries in Sequenced Genomes" 11 june 2024, 14H00 in the room 1A10 at the Biopole building, Campus Brabois Santé.
Summary :
"Identifying the function of every gene in all sequenced organisms is the major challenge of the post-genomic era and an obligate step for any systems biology approach. This objective is far from reached. By various estimates, at least 30-70% of the genes of any given organism are of unknown function, incorrectly annotated, or have only a generic annotation. Using comparative genomic approaches, we have linked genes and functions for around 65 gene families related mainly to coenzyme metabolism, nucleic acid modification, protein modification, and metabolite repair. Building on this body of work I will discuss the lessons learned and what should be the next steps to improve protein function prediction and discovery".